Kinetics: The “Missing Link” For Drug Development Success

Affinity and kinetics are both vital to understand in the drug development process. These binding parameters affect the pharmacodynamics and pharmacokinetics of a drug, the efficacy of the drug, and also the per-dose cost. Most laboratory screening techniques give a ranking of apparent activities or apparent affinities, however many methods are prone to false positives and provide incomplete data on binding parameters.

In this paper, you’ll learn:

  • Why binding kinetics are critical to understand in many different drug development applications
  • Why measurement of only the equilibrium dissociation constant, KD, is insufficient to understand drug-target interactions
  • Why label-free methodologies are critical to obtaining accurate binding data
  • How to utilize biosensors to detect binding partners
  • The drug development questions that can be answered with biosensors
  • What “Enhanced Surface Plasmon Resonance” is and how it works